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The principal cytochrome P450 isoenzyme included seems to generally be CYP2E1, with CYP1A2 and CYP3A4 as additional pathways. Close to eighty five% of an oral dose appears inside the urine in 24 hours of administration, most because the glucuronide conjugate, with compact amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity